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SkinSpan™ Advanced Skin Serum is the result of our effort to develop the most effective solution for the appearance of skin ageing. While developing our best-selling longevity supplements, it became clear that we could further optimise results by delivering selected compounds directly to the skin’s surface. Our unique serum formula is a rich topical complement to your daily care routine, supporting a complete approach to the look and feel of your skin.
SkinSpan™ Advanced Skin Serum is designed to target the visible signs of the four core drivers of skin ageing on the skin's surface:
Developed in Switzerland and designed to complement our oral longevity formulations, SkinSpan™ Advanced Skin Serum combines ingredients that revitalise the appearance of skin vitality, support natural surface renewal, and utilise botanical exosomes to promote a firmer look. By strengthening the skin’s moisture barrier, it targets the visible signs of ageing to support a rejuvenated, youthful appearance over time.
With age, skin can appear tired and lose its natural glow. RejuveNAD™—a bioactive extract derived from nutrient-rich sunflower sprouts—helps revive the appearance of skin's natural vitality. By refreshing the look of the skin, this serum helps it look visibly firmer, smoother, and more energised.
With age, skin can appear tired and lose its natural glow. RejuveNAD™—a bioactive extract derived from nutrient-rich sunflower sprouts—helps revive the appearance of skin's natural vitality. By refreshing the look of the skin, this serum helps it look visibly firmer, smoother, and more energised.
With age, skin can appear duller and its texture rougher, losing its youthful vibrancy. Cellaigie™ is an AI-designed peptide, to support the appearance of visibly renewed skin. It helps reduce the look of surface dullness, revealing visible radiance and a smoother, more youthful-looking texture.
With age, skin can appear less dense, less elastic, and lose definition. PhytoCellTec™ Exosomes, derived from botanical Goji berry stem cells, help improve the appearance of skin density and reduce the look of fine lines and wrinkles — for visibly firmer, more resilient-looking skin.
With age, skin can appear less dense, less elastic, and lose definition. PhytoCellTec™ Exosomes, derived from botanical Goji berry stem cells, help improve the appearance of skin density and reduce the look of fine lines and wrinkles — for visibly firmer, more resilient-looking skin.
A well-functioning moisture barrier helps skin look hydrated and resilient against everyday environmental stressors. Niacinamide (Vitamin B3) helps improve the look of a healthy, balanced moisture barrier, while Ectoin — discovered in microorganisms that survive harsh environments — helps protect the look of skin against the visible signs of environmental stress. Beta-Glucan, naturally derived from yeast, helps soothe the look of redness for visibly comforted, calm-looking skin.
With age, skin can appear tired and lose its natural glow. RejuveNAD™—a bioactive extract derived from nutrient-rich sunflower sprouts—helps revive the appearance of skin's natural vitality. By refreshing the look of the skin, this serum helps it look visibly firmer, smoother, and more energised.
With age, skin can appear duller and its texture rougher, losing its youthful vibrancy. Cellaigie™ is an AI-designed peptide, to support the appearance of visibly renewed skin. It helps reduce the look of surface dullness, revealing visible radiance and a smoother, more youthful-looking texture.
With age, skin can appear less dense, less elastic, and lose definition. PhytoCellTec™ Exosomes, derived from botanical Goji berry stem cells, help improve the appearance of skin density and reduce the look of fine lines and wrinkles — for visibly firmer, more resilient-looking skin.
A well-functioning moisture barrier helps skin look hydrated and resilient against everyday environmental stressors. Niacinamide (Vitamin B3) helps improve the look of a healthy, balanced moisture barrier, while Ectoin — discovered in microorganisms that survive harsh environments — helps protect the look of skin against the visible signs of environmental stress. Beta-Glucan, naturally derived from yeast, helps soothe the look of redness for visibly comforted, calm-looking skin.
Feel the dıfference
SkinSpan™ Advanced Skin Serum is AVEA's premier topical formulation, applying key ingredients directly to the skin's surface. Developed in collaboration with longevity experts in Switzerland, it is designed to support the appearance of healthy, rejuvenated skin as part of AVEA's longevity-inspired daily ritual.
It targets the four core visible signs of skin ageing:
Our range brings together carefully formulated supplements and topical skincare, each developed to the same standard of scientific rigour and premium quality. Together, they offer a sophisticated daily ritual inspired by longevity science.
Use morning and night on damp skin. Face, neck, decollete.
Manufactured in Switzerland
Formulated by Experts
Tested by 3rd Parties
Sustainable Packaging
Clinically proven results
Vegan
INGREDIENTS:
Aqua (Water), Glycerin, Dimethicone, Diglycerin, Niacinamide, Betaine, Dipentaerythrityl Hexacaprylate/Hexacaprate, Ectoin, Maltodextrin, 1,2-Hexanediol, Caprylyl Methicone, Sodium Acrylates Copolymer, Hydroxyacetophenone, Cetearyl Dimethicone Crosspolymer, Isomalt, Lecithin, Polyacrylate Crosspolymer-6, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Tetrasodium Glutamate Diacetate, Potassium Chloride, Sodium Carboxymethyl Beta-Glucan, Helianthus Annuus (Sunflower) Sprout Extract, Sorbitan Isostearate, Caprylyl Glycol, Lycium Barbarum Callus Culture Extract, Acetyl Tetrapeptide-2
We ship worldwide, free delivery above 50£/€/CHF, 5-10 days from dispatch depending on your region.
Formulated with traceable, clinically tested ingredients. Developed and manufactured in Switzerland.
RejuveNAD™
2%Derived from sustainably cultivated organic sunflower sprouts, RejuveNAD™ is a clinically studied botanical ingredient that revitalises the look of tired-looking skin. By supporting the appearance of skin's natural vitality, it helps the complexion look visibly firmer, smoother, and more refreshed over time. This longevity-inspired extract helps skin look more resilient against the visible signs of environmental stress, for a more youthful, energised-looking complexion.
Niacinamide
3%Niacinamide, a bioactive form of Vitamin B3, is a clinically studied ingredient that supports the skin's moisture barrier and promotes the appearance of a renewed complexion. It effectively helps reduce the look of redness, improves the appearance of uneven skin tone, and helps protect the look of skin against everyday environmental stressors.
Cellaigie™
2%Cellaigie™ is a biomimetic peptide composed of natural amino acids, optimised through AI technology to support the appearance of skin's natural surface renewal. It helps reveal a fresher, clearer-looking complexion, reducing the look of surface dullness and refining texture. By supporting the appearance of renewed, radiant-looking skin, it helps the complexion look visibly firmer, more radiant, and more resilient-looking.
PhytoCellTec™ Exosomes
0.4%Derived from botanical Goji berry stem cells, these botanical exosomes help improve the appearance of firmness and density, for skin that looks visibly firmer and more youthful. The result: visibly improved skin density and a reduction in the appearance of fine lines.
Ectoin
2%A high-performance protective compound produced by microorganisms that thrive in extreme environments. It helps the skin's surface look visibly balanced and comforted, and helps protect against the visible signs of environmental stress. By supporting the look of a well-hydrated moisture barrier, Ectoin provides long-lasting hydration, for skin that looks visibly more resilient.
Low Molecular Weight Hyaluronic Acid
<0.1 million DaAn refined form of the skin's natural moisture-binding molecule. Optimised for intensive hydration at the skin's surface, it helps attract and hold moisture — visibly plumping the skin and smoothing the appearance of fine lines. The result: a fuller, more youthful-looking complexion with long-lasting hydration.
Betaine
A natural osmolyte derived from sugar beets that acts as a moisture manager for the skin. It helps attract and hold hydration, keeping skin feeling supple and comfortable. By supporting the feeling of balanced hydration and the moisture barrier, Betaine helps skin feel resilient and moisturised, even under environmental stress.
Beta Glucan
A protective polysaccharide extracted from baker's yeast that helps support the appearance of comforted, resilient-looking skin. It helps soothe the look of redness and promotes a smoother, more resilient-looking surface texture. This soothing molecule helps lock in moisture, for a visibly healthy-looking, vital complexion.
Diglycerin
A sophisticated humectant derived from glycerin that provides superior moisture-binding capacity with an elegant skin feel. Its refined structure provides long-lasting, sustained hydration at the skin's surface, creating a reservoir of moisture. Diglycerin helps support the moisture barrier and helps skin feel hydrated throughout the day, for a smooth, comfortable finish.
Most anti-ageing serums target surface concerns like dryness or fine lines. SkinSpan™ Advanced Skin Serum is built on the principles of skin longevity science, designed to support the appearance of skin's natural processes that contribute to a youthful-looking complexion.
While many formulas rely on a single active, our serum integrates four key pathways:
This comprehensive approach helps skin look visibly more energised, firmer, and more radiant over time.
In the context of skincare, longevity science means our formula is designed to support the appearance of long-term skin vitality. Instead of temporary surface fixes, we use clinically studied ingredients like RejuveNAD™, Cellaigie™, and PhytoCellTec™ Exosomes to support the appearance of skin's natural renewal and vitality. The result: skin that looks visibly more youthful, radiant, and resilient over time.
NAD+ and autophagy are natural cellular processes that have become central concepts in longevity science and research.
SkinSpan™ Advanced Skin Serum is inspired by longevity science. While cosmetic products act only at the skin's surface, we've selected clinically studied ingredients — RejuveNAD™, Cellaigie™, and PhytoCellTec™ Exosomes — whose benefits have been substantiated for the appearance of firmness, radiance, renewal, and vitality.
Yes. SkinSpan™ Advanced Skin Serum is formulated without retinol, exfoliating acids, or fragrance, to minimise the risk of discomfort. It features bioadaptive ingredients like Ectoin and Beta-Glucan, which help soothe the look of redness and support the moisture barrier. The formula is dermatologically tested in Switzerland.
Yes. The serum is compatible with most active ingredients. If you use strong retinoids or chemical exfoliants, we recommend applying SkinSpan™ Advanced Skin Serum first to help support the moisture barrier and the look of comforted skin. Always follow with SPF during the day.
Apply one to two pumps to clean, damp skin twice daily — morning and evening.
Gently press into the face, neck, and décolletage until absorbed. Use before moisturiser or sunscreen during the day, and before your night cream in the evening.
SkinSpan™ Advanced Skin Serum sits within AVEA's broader longevity-inspired range, which also includes AVEA's Collagen Activator and SkinSpan™ Supplement.
A pea-sized amount (one pump) is sufficient for the entire face. The serum is highly concentrated — our formulation features clinically studied active ingredients — so using more does not improve results. Consistency, not quantity, drives the best visible results.
SkinSpan™ Advanced Skin Serum is developed and manufactured in Switzerland under GMP-certified conditions.
The formulation was created in collaboration with leading longevity scientists to ensure precision, stability, and bioavailability of each active compound. Each ingredient is sourced from traceable suppliers with clinical validation and tested for purity and safety.
Yes. SkinSpan™ Advanced Skin Serum and AVEA's supplements are each developed to the same standards of scientific rigour and premium quality, and can be used together as part of a daily ritual.
Each product is formulated to deliver its own benefits within its own category — SkinSpan™ helps revitalise the appearance of skin vitality and firmness at the skin's surface, while AVEA's supplements are formulated to their own nutritional and regulatory standards. Together, they form part of AVEA's broader longevity-inspired range.
SkinSpan™ Advanced Skin Serum is substantiated at two levels: the individual active ingredients are each backed by clinical research, and the finished formula itself has been tested in an 8-week dermatologist-supervised instrumental study conducted in 2026.
In an instrumental use-test of 20 healthy adult volunteers (35–65 years, QACS Laboratory, Athens, 2026), twice-daily application of SkinSpan™ Advanced Skin Serum produced the following statistically significant results:
In the accompanying self-assessment questionnaire, 95% of users found the texture pleasant, 90% felt their skin more elastic and hydrated, and 85% said they would recommend SkinSpan™ to others.
The finished formula is dermatologically tested in Switzerland to verify tolerance and compatibility.
At AVEA, every formulation begins with a deep understanding of the biological processes associated with ageing — and the latest scientific research exploring them. Our work is grounded in emerging findings from the fields of cellular science, metabolism, and longevity research.
Led by our Co-Founder and Chief Science Officer, Sophie Chabloz, our in-house science team collaborates with longevity researchers and biotech experts from leading academic institutions. Together, we translate complex, peer-reviewed research into formulations that reflect the current scientific understanding of longevity.
Each product we create is formulated with clinically studied ingredients and rigorously tested to the highest standards of quality, purity, and scientific evidence.
Your products will be dispatched from our NL warehouse within 24 hours.
We ship internationally and offer a variety of shipping options:
All available shipping methods – along with estimated delivery times and final costs – will be displayed during checkout.
If your country isn’t listed at checkout, feel free to contact our customer service team at support@avea-life.com, and we’ll be happy to explore possible solutions.
While many customers notice a more hydrated and radiant appearance within the first few weeks of use, the full visible effects typically unfold after 2–3 months of consistent use. We offer a 90-day money-back guarantee so you can experience the full visible effects of the serum.
